Joined in 2023 
82 
63 About this deal
Ma Q,et al.(2019). Impact of microbiota on central nervous system and neurological diseases: The gut-brain axis. To a certain extent, the effectiveness of a probiotic supplement will depend on its CFU value (Colony Forming Units — the number of alive and active microbes in one serving). Different CFUs may suit different people, so we make sure to include this in every review.
We updated this article in May 2023 to add more information about each featured product, based on extensive research done by our team. Probiotic supplements may contain bacteria from one genus and/or species only, while others combine several different ones. The manufacturer tests Synbiotic+ for identity and strength. A third-party lab certifies it is free from contaminants. It contains over 8 billion CFU from 12 bacteria strains, including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus gasseri, Lactobacillus rhamnosus, and Lactobacillus acidophilus. Look for a few key extras. A good supplement has time-release technology and delivers a dose of prebiotics—fibers that act as food for probiotic bacteria. “The time-release technology ensures the probiotic reaches your intestine and the prebiotic component aids in absorption,” says Dr. Rajapaksa. Another important extra is third-party certification; seek out a seal of approval from groups like Consumer Lab, NSF International, or the U.S. Pharmacopeial Convention (USP), which ensures the product has been tested for quality, purity, potency, and ingredients.People can do their research into which specific strains might work for their particular condition. A healthcare professional can help with this. Enhances growth performance, better feed utilization, increase in villus height in the duodenum and ileum Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal diseases and is characterized by recurrent abdominal pain associated with changes in stool frequency and form, with no recognized underlying pathological or organic etiology [ 1]. The incidence of IBS varies significantly between countries and regions [ 2]. A meta-analysis published in 2012 revealed that a pooled estimate of international IBS prevalence was 11.2% [ 3]. As there are no specific biomarkers for IBS and the disease is diagnosed clinically based on the Rome criteria, epidemiological data may depend on the criteria used [ 4]. A recent epidemiological survey using the Rome IV criteria revealed that the prevalence of IBS in the general population globally is 4.1% in comparison with 10.1% when the Rome III criteria were used [ 5]. Depending on the predominant alteration in bowel habits, IBS can be classified into diarrhea-predominant IBS (IBS-D), constipation-predominant IBS, and IBS with mixed bowel habits, and IBS-D accounts for about one-third of all IBS cases but with more severe outcomes [ 2]. L. acidophilus NCIMB 30184, L. fermentum NCIMB 30226, L. plantarum NCIMB 30187, and L. rhamnosus NCIMB 30188
Meet the Experts: Roshini Rajapaksa, M.D., a gastroenterologist with NYU Langone Health; Frances Largeman-Roth, R.D.N., a New York City-based nutrition expert.Nurish recommends taking one capsule daily with food and water. It may take two weeks for the effects to be noticeable. These probiotics do not require refrigeration. It's important to look at how many different strains they contain as well as which specific types these are. Nurish claims this product may help combat the negative impact of environmental factors such as chronic stress, poor nutrition, or illness. We always note the type of microbial strains in a probiotic, because it is essential to the supplement’s effectiveness. Meanwhile, supporting ingredients will determine how many of these good bacteria will be able to reach your digestive system intact. The microbiome is unique to each individual, and studies show it may be determined before birth. Research suggests that the microbiome changes throughout a person’s life based on their diet, lifestyle, and exposure to different environmental influences.
The manufacturer states the ingredients have been clinically studied for their effect on weight management. The study found that participants regularly taking the probiotics experienced a 5% average reduction in visceral and subcutaneous body fat. The aim of the current RDBPC trial was to determine whether the multi-strain probiotic consists of the mixture of five Lactobacillus species ( Lactobacillus rhamnosus LR110, Lactobacillus paracasei LPC100, Lactobacillus acidophilus LA120, Lactobacillus casei LC130, Lactobacillus plantarum LP140), four Bifidobacterium ( Bifidobacterium breve BB010, Bifidobacterium longum BL020, Bifidobacterium bifidum BF030, Bifidobacterium lactis BL040) species, and Streptococcus thermophilus ST250 would be safe and effective in improving global symptom severity (measured with the use of the IBS-SSS and IBS-GIS) in patients with IBS-D. The results of our study showed the probiotic group to be superior to the placebo group in terms of primary outcomes. This was largely due to the observed benefit in improving the severity of abdominal pain and quality of life. Our results are consistent with the findings that multispecies combinations of probiotic strains have significant effects on IBS symptoms [ 28, 29, 37, 38]. Recently published systemic review and meta-analyses show that multispecies combinations of probiotic strains are superior to single strain preparations [ 28, 29], but in contrast Liang et al. conclude that single probiotics seem to be better choice as they affect specific symptoms—e.g., bloating [ 25]. The pathogenesis of IBS is multifactorial with no single etiology but with wide spectrum of abnormalities including motility disturbances, visceral sensitivity, altered mucosal immune functions, increased intestinal permeability, disturbances in gut microbiota composition, or altered sensory neuron activation and central nervous system processing [ 1, 6]. There has been increasing focus on the possible connections between these conditions [ 6, 7, 8]. It is currently assumed that the intestinal dysbiosis may be a main factor responsible for most of the pathological conditions described [ 9, 10]. The intestinal dysbiosis, also known as the gut microbiota dysbiosis, is defined as a condition in which there is an imbalance of the microorganisms and their functional activities within the intestines [ 11]. Medina M, Izquierdo E, Ennahar S, et al. Differential immunomodulatory properties of Bifidobacterium longum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol. 2007;150:531–538. People should speak to their gastroenterologist for specific probiotic guidance and recommendations based on their health conditions and goals. Which probiotics actually work?
Transform your health
IPA Admin. (2021). Probiotic modulation of the microbiota-gut-brain axis – a role for gender and age. In particular, the probiotic yeast Saccharomyces boulardii has effectively prevented and treated diarrhea that occurs when taking antibiotics or following infection. The yeast may also effectively treat irritable bowel syndrome and inflammatory bowel disease, but more research is needed to confirm this. Probiotics for constipation
Great Deal 
New Comment