Cabergoline for men & women: Dostinex (Know Your Medicine)

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For people with history of tissue scarring: If you have a history of scarred tissue in your lungs, heart, kidney, or abdomen (stomach area), you should not use this drug. It can make your condition worse. For women who are breastfeeding: It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breastfed. This drug may also keep you from making breast milk. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. Cabergoline is used to treat hyperprolactinemia (high levels of prolactin in your body). This happens when your pituitary gland makes extra prolactin. High prolactin levels may be caused by a hormone problem or by a tumor in your pituitary gland. Before taking Caberlin (Cabergoline) tablets, a medical consultation will be necessary, to allow your doctor to prescribe the correct dosage for you. Adults treating hyperprolactinemia may be prescribed an initial dose of 0.25mg taken by mouth, twice per week. The prescribing doctor may decide to increase this by 0.25mg taken twice a week. The maximum dosage is usually 1mg taken twice per week. It is important for patients to note that the dosage prescribed can depend on the patient`s serum prolactin levels, and for this reason, it is very important to follow the prescribing doctor`s instructions.

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If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist. Serious side effects Cabergoline oral tablet is a prescription drug that’s only available as a generic drug. There is no brand-name version available. Cabergoline only comes as a tablet you take by mouth. Why it’s used Dosage increases: Your doctor may increase your dosage by 0.25 mg. This decision depends on your prolactin levels. Your doctor may increase your dosage once every 4 weeks. Cabergoline is a tablet treatment used to reduce the production of a hormone called prolactin by the pituitary gland (a gland at the base of the brain). If you have a prolactinoma (overproduction of prolactin by a cluster of cells in the pituitary), cabergoline treatment is also used to shrink the size of the swelling on the pituitary gland. How should I take cabergoline?

Cabergoline Uses and Dosage

Cabergoline is a long-acting medication, usually taken once or twice a week. Cabergoline can make you feel a bit dizzy, or cause nausea or headaches. Side-effects may be reduced if you take the cabergoline with food, or last thing at night before going to bed. Usually your specialist will recommend a low starting dose to reduce the risk of side-effects, gradually increasing the dose if necessary as your body gets used to the medication. Rare side-effects of cabergoline If you stop taking the drug suddenly or don’t take it at all: The levels of prolactin in your blood will stay high. In women, high prolactin levels can change ovulation, menstrual cycles, and breast milk production. In men, high prolactin levels can affect reproduction and cause sexual issues. These include a decreased sex drive and not being able to get or keep an erection. If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

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You should not take cabergoline with erythromycin or clarithromycin (these are types of antibiotics), as they increase the cabergoline level in the blood, increasing the risk of sideeffects. You should also avoid domperidone and metoclopramide (sometimes used to treat nausea or vomiting), as they counter-act the effect of the cabergoline. Are there alternatives to cabergoline treatment? Mehmed S, Casanueva FF, Hoffman AR, et al. 2011. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(2):273-88 Molitch ME. 2015. Endocrinology in pregnancy: management of the pregnant patient with a prolactinoma. Eur J Endocrinol 172(5):R205-13. www.zums.ac.ir Opens a new window [Accessed October 2016]For people with high blood pressure from pregnancy: If you’re currently pregnant and have high blood pressure from your pregnancy, you should not use this drug. It can make your condition worse. If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death). Warnings for people with certain health conditions Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following. Cabergoline, known as Caber to bodybuilders and athletes, is a dopamine agonist that is made to reduce the levels of prolactin in the body. A lot of athletes use it to combat the elevated prolactin levels that you get in Injectable and Oral Steroids like Nandrolone and Trenbolone. This is especially important for people that are prolactin sensitive and want to avoid those nasty side effects that so often come from those kinds of compounds. Buying Cabergoline Can Improve Your Sleep and Sex Drive Talk to your doctor if you’re pregnant or plan to become pregnant. Animal studies do not always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed.

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Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold. Cabergoline is sometimes given to women who are not ovulating due to a high level of prolactin in their body. It can also be used for men who are having issues with their reproductive system due to high levels of prolactin within the body. Depending on your prolactinoma, your symptoms and your situation, you may need no treatment at all, or there may be alternatives such as oestrogen or testosterone treatment. If you are not able to tolerate treatment with cabergoline, or if it is not effective in your case, there are similar medications that can be considered, or other treatment options including pituitary surgery. Your endocrinologist will discuss the options with you. Other information There are some much rarer side-effects of cabergoline. Very rare cases of heart valve damage have been reported. Usually your doctor will listen to your heart before starting cabergoline treatment, and they may arrange an echocardiogram heart scan. This scan may be repeated if you need long-term treatment. It is very unusual for cabergoline to cause clinically significant heart problems, but you should alert your doctor if you developed shortness of breath or ankle swelling.Cabergoline oral tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed. For people with liver problems: You may not be able to process this drug well. This may increase the levels of the drug in your body and cause more side effects. Warnings for other groups Cabergoline can be taken along-side Clomiphene within your treatment for infertility. This can have the added benefit of, not only starting to be able to ovulate, but also lowering the risk of having multiple eggs fertilised at once. This means that you will not run the risk of having twins or triplets while trying to conceive a baby. Cabergoline Uses and Dosage

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If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times. Cabergoline oral tablet can cause drowsiness as well as other side effects. More common side effects Also very rarely, cabergoline can cause psychiatric disturbances or abnormally impulsive behaviour, for example a strong desire to gamble or a greatly increased sex drive. It is worth letting your ‘nearest and dearest’ know about this, just in case they notice any changes of this sort. If you are concerned you should consult your GP or your endocrinologist. These problems usually settle when the treatment is stopped. How is the response to cabergoline treatment monitored?

BNF. 2016. Endocrine system. British National Formulary. www.evidence.nhs.uk Opens a new window [Accessed October 2016]