Bee Health Propolis Lozenges 114 g Pack of 2

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Oliveira, A. C., Shinobu, C. S., Longhini, R., Franco, S. L., and Svidzinski, T. I. Antifungal activity of propolis extract against yeasts isolated from onychomycosis lesions. Mem.Inst Oswaldo Cruz 2006;101(5):493-497. View abstract.

Be cautious with this combination • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PROPOLIS Coelho, L. G., Bastos, E. M., Resende, C. C., Paula e Silva CM, Sanches, B. S., de Castro, F. J., Moretzsohn, L. D., Vieira, W. L., and Trindade, O. R. Brazilian green propolis on Helicobacter pylori infection. a pilot clinical study. Helicobacter. 2007;12(5):572-574. View abstract. Freitas, S. F., Shinohara, L., Sforcin, J. M., and Guimaraes, S. In vitro effects of propolis on Giardia duodenalis trophozoites. Phytomedicine 2006;13(3):170-175. View abstract.Schnitzler P, Neuner A, Nolkemper S, et al. Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother Res. 2010;24 Suppl 1:S20-S28. doi:10.1002/ptr.2868 Koo HJ, Lee KR, Kim HS, Lee BM. Detoxification effects of aloe polysaccharide and propolis on the urinary excretion of metabolites in smokers. Food Chem Toxicol. 2019;130:99-108. View abstract. Cai T, Tamanini I, Cocci A, et al. Xyloglucan, hibiscus and propolis to reduce symptoms and antibiotics use in recurrent UTIs: a prospective study. Future Microbiol. 2019;14:1013-1021. View abstract. Poppe, B. and Michaelis, H. [Results of a twice-yearly controlled oral hygiene activity using a propolis-containing toothpaste (double-blind study)]. Stomatol.DDR. 1986;36(4):195-203. View abstract.

Samet N, Laurent C, Susarla SM, Samet-Rubinsteen N. The effect of bee pollen on recurrent aphthous stomatitis. A pilot study. Clin Oral Investig 2007;11:143-7. View abstract. Propolis might slow blood clotting. Taking propolis along with medications that also slow blood clotting might increase the risk of bruising and bleeding.Bruyère F, Azzouzi AR, Lavigne JP, et al. A multicenter, randomized, placebo-controlled study evaluating the efficacy of a combination of propolis and cranberry (Vaccinium macrocarpon) (DUAB®) in preventing low urinary tract infection recurrence in women complaining of recurrent cystitis. Urol Int 2019;103(1):41-8. View abstract. The antimicrobial activity of five propolis samples collected from four different regions in Turkey and from Brazil against nine anaerobic ( Peptostreptococcus anaerobius, Peptostreptococcus micros, Prevotella oralis, Prevotella melaninogenica, Porphyromonas gingivalis, Fusobacterium nucleatum, Veillonella parvula, Lactobacillus acidophilus, and Actinomyces naeslundii) strains was evaluated and determined minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of EEP on the growth of test microorganisms by using agar dilution method. All strains were susceptible and MIC values ranged from 4 to 512mg/mL for propolis activity. Propolis from Kazan-Ankara showed most effective MIC values to the studied microorganisms. MBC values of Kazan-Ankara EEP samples ranged from 8 to 512mg/mL. Death was observed within 4h of incubation for Peptostreptococcus anaerobius and micros and Lactobacillus acidophilus and Actinomyces naeslundii, while being 8h for Prevotella oralis, Prevotella melaninogenica, and Porphyromonas gingivalis, 12h for Fusobacterium nucleatum, and 16h for Veillonella parvula. It was shown that propolis samples were more effective against Gram-positive anaerobic bacteria than Gram-negative ones. Propolis is used in oral cavity diseases as it contains flavonoids such as pinobanksin, quercetin, naringenin, galangine, chrysin, and aromatic acids such as caffeic acid determined by GC-MS analysis [ 77].

Miyares, C., Hollands, I., Castaneda C, and et al. [Clinical trial with a preparation based on propolis "propolisina" in human giardiasis]. Acta Gastroenterol.Latinoam. 1988;18(3):195-201. View abstract. Esposito C, Garzarella EU, Bocchino B, et al. A standardized polyphenol mixture extracted from poplar-type propolis for remission of symptoms of uncomplicated upper respiratory tract infection (URTI): a monocentric, randomized, double-blind, placebo-controlled clinical trial. Phytomedicine 2021;80:153368. View abstract. Guler E, Bilir O, Osman Kocak A, Atas I, Tanugur Samanci AE. The prophylactic efficacy of Anatolian propolis in individuals at high risk of COVID-19. Eur Rev Med Pharmacol Sci. 2022;26(2 Suppl):53-60. View abstract. Gregory SR, Piccolo N, Piccolo MT, et al. Comparision of propolis skin cream to silver sulfadiazine: a naturopathic alternative to antibiotics in treatment of minor burns. J Altern Complement Med 2002;8:77-83. View abstract.

REVIEWS - Manuka Honey Lozenges with Propolis Lemon & Honey

Jautová J, Zelenková H, Drotarová K, Nejdková A, Grünwaldová B, Hladiková M. Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage): randomized, controlled double-blind study. Wien Med Wochenschr 2019;169(7-8):193-201. View abstract.

The effect of ethanolic extract of propolis against experimental diabetes mellitus-associated changes was examined. Diabetes was induced experimentally in rats by i.p. injection of streptozotocin (STZ) in a dose of 60mg/kg bwt for 3 successive days. Blood urea nitrogen (BNU), creatinine, glucose, lipid profile, malondialdehyde (MDA), and urinary albumin were measured. Superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), and MDA were measured in the renal tissue. The results showed decreased body weight and increased kidney weight in diabetic animals. Compared to the control normal rats, diabetic rats had higher blood glucose, BNU, creatinine, total cholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-C), MDA and urinary albumin, and lower high-density lipoprotein-cholesterol (HDL-C) levels. Moreover, renal tissue MDA was markedly increased while SOD, GSH, and CAT were significantly decreased. Oral administration of propolis extract in doses of 100, 200, and 300mg/kgbwt improved the body and kidney weights, serum glucose, lipid profile, MDA, and renal function tests. Renal GSH, SOD, and CAT were significantly increased while MDA was markedly reduced. These results may suggest a strong antioxidant effect of propolis which can ameliorate oxidative stress and delay the occurrence of diabetic nephropathy in diabetes mellitus [ 74]. According to Kumar et al., the antimicrobial property of propolis collected from Gujarat by agar diffusion method against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Asparagus nigar. Ethanolic extracts of sample (conc. 200mg/mL) showed high antibacterial activity against Gram-positive, that is, Bacillus subtilis, but least activity against Gram-negative bacteria ( P. aeruginosa and E. coli). The yeast C. albicans showed the moderate zone of inhibition whereas A. Niger did not show any activity. However, the least was in the 40% methanolic extracts [ 16]. One of the most important effects of antioxidants is the way they reduce your cancer risk. They help minimize free radicals, which can damage your cells in a way that makes them dangerous. Flavonoids and polyphenols may lower your risk of developing certain medical conditions, such as heart disease.The antitumor activity of propolis was reviewed by Orsolic et al. The chemopreventive activity of propolis in animal models and cell cultures is likely to be the result of their ability to inhibit DNA synthesis in tumour cells, their capability to induce apoptosis of tumour cells, and their property to activate macrophages to produce factors capable of regulating the function of B, T and NK cells, respectively. Moreover, these results suggest that flavonoids from propolis play a protective role against the toxicity of the chemotherapeutic agents or radiation in mice, giving hope that they may have similar protective action in humans. The combination with an adjuvant antioxidant therapy may enhance the effectiveness of chemotherapy by ameliorating the side effect on leukocytes, liver, and kidneys and consequently enabling dose escalation [ 63]. Although many polyphenols have an antimetastatic activity, caffeic acid phenethyl esters (CAPE) from poplar propolis and Artepillin C from Baccharis propolis have been identified as the most potent antitumor agents [ 64– 68]. Honey — although propolis is usually completely removed it may be added for its purported therapeutic effect Martinez, Silveira G., Gou, Godoy A., Ona, Torriente R., and et al. [Preliminary study of the effects of propolis in the treatment of chronic gingivitis and oral ulceration]. Rev Cubana Estomatol. 1988;25(3):36-44. View abstract.