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May help maintain the integrity of the stomach lining and a proper gastric immune response Footnote † Over time, the delicate gut lining can become weak and more permeable than normal (due to things like gluten, periodic stress, too much exercise, unhealthy balance of gut bacteria, not eating as well as you should, pesticides and more, which can show up in the form of a variety of stomach discomforts, such as occasional: Zinc – People with zinc deficiency will generally suffer from digestive disturbances, especially difficulty digesting protein. This is because zinc is necessary for producing strong enough stomach acids. If the food isn’t broken down properly, then nutrients in the food don’t get absorbed into the body. Are the ingredients in Doctor’s Best PepZin GI safe?
Xing, L.; Chee, M.E.; Zhang, H.; Zhang, W.; Mine, Y. Carnosine—A natural bioactive dipeptide: Bioaccessibility, bioavailability and health benefits. J. Food Bioact. 2019, 5, 8–17. [ Google Scholar] [ CrossRef][ Green Version]And even more severe issues. For instance, a systematic review published in the journal Advances in Integrative Medicine found that increased intestinal permeability coincides with a variety of health conditions. In fact, the researchers found that upwards of 80% of folks with certain health problems also had increased intestinal permeability. 1 Learning all the natural ways of relieving and preventing gas, gluten intolerance, IBS, lactose intolerance, bloating, diarrhea and constipation along with taking Doctor’s Best PepZin GI is something that you will be happy about in the future. Achieving the best results in relieving digestive issues can’t be relied solely on Doctor’s Best PepZin GI. If you are at the point where your digestive issues become unbearable then committing to a proper diet and changes in your lifestyle are just as crucial as taking anything over the counter. Adhering to a low sugar diet is one of the bigger commitments women will have to make in relieving and preventing digestive problems. Misawa, T.; Chijiiwa, Y.; Nawada, A. Clinical study of Z-103: Clinical effects on gastric ulcer and influence on endocrine dysfunction. Jpn. Pharm. Ther. 1992, 20, 245–254. [ Google Scholar]
Have you been struggling for a while and feel like you’ve “tried everything” with little to no results to show? Rasmussen, V.F.; Vestergaard, E.T.; Hejlesen, O.; Andersson, C.U.N.; Cichosz, S.L. Prevalence of taste and smell impairment in adults with diabetes: A cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES). Prim. Care Diabetes 2018, 12, 453–459. [ Google Scholar] [ CrossRef]
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Manage stress in healthy ways by setting boundaries, practicing yoga, doing deep breathing exercises, meditating, expressing gratitude, praying and spending time in nature. That alone highlights how important good gut health is to a robust, properly functioning immune system. But there’s even more to the gut-immune system relationship. For example, a healthy, properly functioning gut lining (i.e., barrier) and a normal/optimum pH balance are important components of the natural defense mechanisms of the stomach. What Can You Do to Support Gut Health and a Healthy Immune System? Ishihama et al. reported that a ZnC mouth rinse was effective for improving oral mucosal injury in 423 patients who were experiencing symptoms of oral mucosal injury as a result of cancer treatment. Effects of the ZnC rinse were examined according to the cancer treatment method: The stomatitis prevention success rate, symptom improvement rate, pain prevention success rate, and symptom improvement rate were 68.5%, 84.4%, 75.4%, and 76.7%, respectively, for chemotherapy ( n = 280); 32.7%, 64.5%, 45.5%, and 73.5% for chemoradiation therapy ( n = 95); and 29.6%, 60.0%, 40.7%, and 68.6% for radiotherapy alone [ 25]. May help relieve periodic GI discomfort, such as upset stomach, gas, bloating, nausea and heartburn Footnote † Providing support for periodic GI discomfort, including occasional heartburn, tenderness, diarrhea and constipation Footnote †
Murakami, Y.; Koyabu, T.; Kawashima, A.; Kakibuchi, N.; Kawakami, T.; Takaguchi, K.; Kita, K.; Okita, M. Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon α-2b and ribavirin. J. Nutr. Sci. Vitaminol. 2007, 53, 213–218. [ Google Scholar] [ CrossRef][ Green Version] Miyoshi, A. Clinical evaluation of Z-103 in the treatment of gastric ulcer, a multicenter double-blind dose finding study. Yakuri Chiryo 1992, 20, 181–197. [ Google Scholar] Zinc carnosine helps to reduce and relieve the symptoms of mild gastritis including GIT pain, nausea, abdominal distention and relieves symptoms of heartburn. Lactobacillus rhamnosus maintains beneficial gut flora during antibiotic use and restores benefical gut flora after antibiotic use. PepZin Pro contains zinc carnosine which helps to relieve symptoms of mild gastritis including gastrointestinal pain, nausea, abdominal distension and relieves symptoms of heartburn. Lacidofil (Lactobacillus rhamnosusR0011 andLactobacillus helveticusR0052) relieves symptoms of medically diagnosed irritable bowel syndrome and relieves diarrhoea.Lactobacillus rhamnosusmaintains beneficial gut flora during antibiotic use and restores beneficial flora after antibiotic use and probiotics support digestive system health and function. Zinc further supports immune system health and function. What’s more, glutamine is essential for supporting gut barrier integrity. Physical, mental, emotional, and environmental stress increase the body’s use of this key gut-nourishing nutrient. A meta-analysis (the gold standard of scientific evidence) found that glutamine reduced markers of increased intestinal permeability. And a research review stated that “glutamine holds great promise” in protecting the gut and for enhancing gut barrier health and function. 5,6
A significant decrease of serum transaminase activities (ALT) was observed in 12 chronic hepatitis C patients who received daily supplementation of 150 mg of ZnC for 48 weeks during combination therapy comprising PEG-IFN-2b plus ribavirin compared to controls ( n = 12). All patients received 300 mg of vitamin E and 600 mg of vitamin C. Supplementation with ZnC decreased plasma thiobarbituric acid reactive substances (TBARS) concentration and prevented the decrease in erythrocyte polyunsaturated fatty acid (PUFA) levels. The authors hypothesized that the ZnC exerted its benefit via its antioxidant properties and that the PUFA levels were evidence of a decrease in lipid peroxidation. They suggested that since zinc is absorbed in the small intestine and transported to the liver via the portal vein, hepatocytes may be exposed to higher levels of zinc than other tissues, especially during supplementation. The authors concluded that ZnC may offer antioxidant protection for chronic hepatitis patients undergoing treatment [ 20]. The selective permeability of the gut lining is regulated by specific structures. These structures are called “tight junctions.” Over time, these can become “loose,” resulting in increased intestinal permeability (aka leaky gut). It has been reported that patients with chronic liver disease show impaired trace element metabolism. Specifically, high levels of iron and copper, and low levels of zinc, selenium, phosphorus, calcium, and magnesium [ 62]. Because of its antioxidant and anti-inflammatory effects, it has been hypothesized that supplemental zinc would be beneficial as an adjunct to treatments for chronic hepatitis C. It has been reported that zinc supplementation enhances the response to interferon therapy in patients with intractable chronic hepatitis C [ 63].
Ito, M.; Shii, D.; Segami, T.; Kojima, R.; Suzuki, Y. Preventive actions of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) through increases in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol-induced gastric mucosal damage in rats. Jpn. J. Pharmacol. 1992, 59, 267–274. [ Google Scholar] [ CrossRef] [ PubMed][ Green Version] L-Glutamineprovides support for intestinal health and mucosal integrity, and it also provides nutritional support for immune system cells in the gut. Footnote †In an ethanol-induced gastro-injury rat model, ZnC treatment decreased the ulcer index of the rat stomach and showed a significant ulcer-healing effect similar to the gastric mucoprotective agent rebamipide [ 31]. Similarly, a significant ulcer healing effect was reported with ZnC supplementation compared with the placebo treatment group in an aspirin-induced gastroduodenal injury animal model [ 32, 33]. In addition, a study using an acetic acid-induced rat model reported that the ZnC treatment group showed a significant antiulcer effect and healing action compared to the control [ 34]. These results are most likely a result of the anti-inflammatory and antioxidant functions of ZnC [ 35]. This function of ZnC helps to explain the many other benefits it can exert throughout the GI tract.
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