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Plus, IHN is significantly less effective than nicotinic acid at increasing serum niacin. IHN usually takes between 6-12 hours to raise blood levels of niacin to near the optimal range ( 28).
Overall, the evidence indicates that nicotinic acid supplementation improves blood lipid profiles but has no significant effects on risk of cardiovascular events. Although nicotinic acid is a nutrient, if very high doses (thousands of mg) are taken to treat hyperlipidemias, the supplement is being used as a drug. Such doses should only be taken with medical approval and supervision. Health Risks from Excessive NiacinHowever, niacin is only effective as a cholesterol treatment at fairly high doses. These doses could pose risks, such as liver damage, gastrointestinal problems, or glucose intolerance. So don't treat yourself with over-the-counter niacin supplements. Instead, get advice from your health care provider, who can prescribe FDA-approved doses of niacin instead if recommended. It's better to take flush niacin if you are seeking benefits such as regulating already-healthy HDL and LDL cholesterol levels because no-flush niacin does not reliably have the same effects on lipids and cholesterol. If you really can't tolerate the flush, or your main goal is not to target lipids (fats), flush-free niacin is a good option. Both inositol hexanicotinate and niacinamide (nicotinamide) are flush-free. If you’re wondering how long or how often to do a niacin flush as well proper dosage, always speak to your health care provider. Typically, doctors advise taking niacin with food and gradually increasing niacin dosage over the course of several weeks. Niacin extended-release supplements are often recommended. This version of niacin is designed to reduce the chance of skin flushing. There’s research to suggest that niacin could help protect those cells and possibly even lower the risk of type 1 diabetes in children who have a higher chance of developing this condition ( 10). If you have any of these health concerns, especially diabetes or gallbladder disease, speak with your doctor before taking niacin. In general, always speak to your doctor before conducting a niacin flush. Some doctors recommend combining statins with niacin, which can increase the risk of side effects.
The flushing occurs with over-the-counter immediate-release niacin tablets. With this type of niacin the vitamin is delivered to the body in a short burst and the flushing reaction is more intense. Taking the following contraindicative medications: zinc, aspirin, blood pressure drugs, alcohol, chromium, statins, and diabetes drugs Niacin is water-soluble, so your body does not store it. This also means that your body can excrete excess amounts of the vitamin through urine if they are not needed ( 1). tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, According to a 2017 study, taking aspirin alongside niacin may help reduce the effects of flushing.
Your dose needs may change if you switch to a different brand, strength, or form of this medicine. Avoid medication errors by using only the form and strength your doctor prescribes. For specific health concerns, some people intentionally take higher doses of niacin, which is also referred to as a niacin flush because they are basically flushing their bodies with niacin. That’s the type of niacin flush I’m focusing on here. Is a niacin flush good for you? Research has shown that it can helpful for certain people. Period symptoms and premenstrual syndrome in women are often associated with vitamin deficiencies. Vitamin B3 is known for regulating sex and stress hormones, which evidence links with menstruation. Niacin supplements should be treated like a drug and only taken under medical supervision, since they can have side effects. SUMMARY Increase HDL (good) cholesterol. It prevents the breakdown of apolipoprotein A1, which is used to make HDL (good) cholesterol. It can increase HDL (good) cholesterol by up to 20–40% ( 1, 12).
Jacobson TA. A "hot" topic in dyslipidemia management - "How to beat a flush": Optimizing niacin tolerability to promote long-term treatment adherence and coronary disease prevention. Mayo Clin Proc. 2010;85(4):365-79. Niacin effectively increases HDL, which improves cholesterol. An increase in HDL is effective in removing bad cholesterol and plaque from the arteries. In time, this can reduce heart conditions. Is niacin flush safe?Anyone with the following medical concerns should avoid taking niacin: liver conditions, kidney or heart issues, those taking certain medications (see the list above), type 2 diabetes, stomach ulcers, thyroid patients, people with allergies, and drug and alcohol addiction. Does niacin remove plaque from the arteries? You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch. Niacin (B3; nicotinic acid) oral. Facts & Comparisons eAnswers. http://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed Aug. 9, 2017. For example, individuals may take 100 mg of niacin twice daily with meals for the first week, then double the daily amount each week until they reach the prescribed amount. People can discuss with a healthcare professional whether this is safe for them.
A niacin flush (the visible symptom) typically occurs from supplemental doses of niacin at 50 milligrams or higher. When niacin is consumed in foods, it is not likely to experience the visible niacin side effect known as a niacin flush. However, high doses of niacin can cause other, more dangerous side effects, although these are rare ( 20). The goal of this small 2013 study was to look at the impact of 12 weeks of niacin treatment on the lipid profile and oxidative stress status in patients with low levels of HDL cholesterol, specifically where good cholesterol was less 40 mg/DL. Both low HDL levels and oxidative stress are typically indicative of a higher risk for heart problems. Stop taking niacin or niacinamide at least two weeks before surgery. It’s possible for niacin to make allergies worse by increasing histamine levels in the body.
A niacin flush can be a temporary side effect of taking niacin; it’s also a protocol used by some physicians to lower lipid profiles and boost heart health. Niacin flush is a very common side effect of taking the immediate-release form of nicotinic acid. It’s so common that at least half of people who take high doses of immediate-release niacin supplements experience it ( 4, 5). Pellagra is a rare health condition resulting from a deficiency in vitamin B3. Alcoholics as well as people with HIV/AIDS are risk for developing pellagra. Niacin is approved by the FDA as a pellagra treatment. ( 13)
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