URGOTUL AG/Silver Plasters 10 x 12 cm

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With the increase in the incidence of diabetes and chronic vascular diseases, wound management (especially for certain chronic wounds) has gradually attracted the attention of clinicians. The poor healing of wounds results in pain to patients and causes a heavy medical burden. For example, DFU can cause severe and persistent infections and, in extreme cases, lead to amputation. The use of dressings is a common treatment for the management of wounds. In particular, modern dressings are superior to traditional dressings in preventing infection, accelerating wound healing, and reducing pain in patients. The selection of the most appropriate modern dressing product is a challenge for clinicians. An ideal dressing should have the ability to maintain moisture balance in the wound, promote oxygen exchange, isolate proteases, stimulate growth factors, prevent infection, facilitate autolytic debridement, and promote the production of granulation tissue and re-epithelialization (Moura et al., 2013). Medihoney Gel Sheet is a sterile, non-adherent wound dressing made from Medihoney Antibacterial Honey (80%w/w) and Sodium Alginate for wound care (20%w/w). Chapman S. (2017). Venous leg ulcers: an evidence review. Br. J. Community Nurs. 22, S6–S9. 10.12968/bjcn.2017.22.Sup9.S6 [ PubMed] [ CrossRef] [ Google Scholar] Broughton G., II, Janis J., Attinger C. E. (2006). A brief history of wound care. Plast. Reconstr. Surg. 117, 6S−11S. 10.1097/01.prs.0000225429.76355.dd [ PubMed] [ CrossRef] [ Google Scholar] Appropriate secondary dressings are C-View (film) or Biatain Silicone (foam) depending on the exudate level, location and skin state

Edmonds M, et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-196. Silver wound dressing that is fast and powerful at killing bacteria, destroys biofilms and prevents reformation. Kuo C. Y., Wootten C. T., Tylor D. A., Werkhaven J. A., Huffman K. F., Goudy S. L. (2013). Prevention of pressure ulcers after pediatric tracheotomy using a mepilex ag dressing. Laryngoscope 123, 3201–3205. 10.1002/lary.24094 [ PubMed] [ CrossRef] [ Google Scholar]Venous leg ulcers occur in 1–3% of the adult population and account for the majority of lower extremity ulcerations (1), and are an important patient health and safety concern. The prevalence of venous leg ulcers ranges from 0·6 to 1·6 per 1000 for the total adult population, increasing between 10 and 30 per 1000 in the population over the age of 85 years 2, 3, 4. Despite recent advances in wound care, ulcers can take months to heal, have frequent complications (e.g. infections and cellulitis), often recur, and are costly to treat (5). The refractory nature of venous leg ulcers can affect a patient's quality of life and productivity at work, causing significant morbidity (6). These products should be used on specialist advice only. Tissue Viability referral must be completed prior to Venturi products being prescribed.

Ascione F., Guarino A. M., Calabro V., Guido S., Caserta S. (2017b). A novel approach to quantify the wound closure dynamic. Exp. Cell Res. 352, 175–183. 10.1016/j.yexcr.2017.01.005 [ PubMed] [ CrossRef] [ Google Scholar]If necessary, cover UrgoClean Ag with a secondary dressing suitable for the wound location and level of exudate. There are many factors involved in wound healing (Guo and Dipietro, 2010). The healing process is not static and growth involves four different phases, namely coagulation and hemostasis, inflammatory, proliferation, and remodeling. These phases are not independent but partially overlap on the basis of a sequence by hemostasis, inflammatory, proliferation, and remodeling (Kasuya and Tokura, 2014; Wilhelm et al., 2017). After skin injury, the wound or tissue fracture is filled with blood clots, followed by acute inflammation of the surrounding tissue. The release of inflammatory mediators and infiltration of inflammatory cells cause tissue swelling and pain. Proliferative fibroblasts, endothelial cells, and newly formed capillaries interact to form granulation tissue filling the crevices. During the shaping period, the scars are softened without affecting the tensile strength through the action of various enzymes and stress, thereby adapting to physiological functions (Jeffcoate, 2012; Harper et al., 2014; Nuutila et al., 2016; Ascione et al., 2017a, b).

Barnea Y., Weiss J., Gur E. (2010). A review of the applications of the hydrofiber dressing with silver (Aquacel Ag) in wound care. Ther. Clin. Risk Manage. 6, 21–27. 10.2147/TCRM.S3462 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Alvarez O. (1988). Moist environment for healing: matching the dressing to the wound. Ostomy Wound Manage. 21, 64–83. [ PubMed] [ Google Scholar]O'Meara S., Martyn-St James M. (2013). Alginate dressings for venous leg ulcers. Cochrane Database Syst. Rev. 4:CD010182 Subject demographics, baseline characteristics, leg ulcer history and the number of pre‐defined local signs were recorded at baseline and an index leg was selected (in the case of bilateral ulceration). A baseline acetate tracing of the wound surface area was also taken. The ulcer was covered on its whole surface by the test dressing followed by a sterile absorbent pad. A (UK) Class III compression system was applied to deliver an appropriately high level of compression. Both dressings were changed based on the clinical condition of the wound and the volume of exudate. Dressing changes were carried out by a health care professional either at the subjects' homes or in the clinic. For subjects wearing compression hosiery, dressing changes could have been performed by the subject at home at the discretion of the investigator. At each dressing change, wounds were inspected and cleaned exclusively with normal saline or warm water. If necessary, mechanical debridement could have been performed to remove slough and necrotic tissue. Meaume et al. The importance of pain reduction through dressing selection in routine wound management: the MAPP study, Journal of Wound Care, 2004, Vol 13, No 10, 409-413. Parpex P. et al. Management of venous leg ulcers with Cellosorb® Micro-adherent dressing: results of a multi-centre clinical trial. Phlebologie 2010; 63: 76-82. Augustin M, Keuthage W, Lobmann R, Lützkendorf S, Groth H, Möller U, Thomassin L, Bohbot S, Dissemond J, Blome C. Clinical evaluation of UrgoStart Plus dressings in real-life conditions: results of a prospective multicentre study on 961 patients. J Wound Care. 2021 Dec 2;30(12):966-978. doi: 10.12968/jowc.2021.30.12.966. PMID: 34881999.