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Before the rash appears, there is usually a prodromal illness of several days duration resembling an upper respiratory tract infection or 'flu-like illness. Symptoms may include:

Topical antiseptics can be used (eg, silver nitrate, chlorhexidine [but not silver sulfadiazine as it is a sulfa drug]) It is more often seen with drugs with long half-lives compared to even a chemically similar related drug with a short half-life. A half-life of a medication is the time that half of the delivered dose remains circulating in the body. Corsair's commitment to PC cases means that it's able to offer great options both at the very high end, such as the enormous 1000D, but also in the more modest, budget section of the market. Here, that's ably represented by the Corsair Carbide 275R, an affordable mid-tower chassis that looks anything but. Eosinophilia (raised eosinophil count) and atypical lymphocytosis (odd-looking lymphocytes) do not occur. Which you'll still be able to show off because you get a full height acrylic side panel—though you can buy a more expensive tempered glass version—that gives you a great view of your gaming rig's innards.The role of systemic corticosteroids (cortisone) remains controversial. Some clinicians prescribe high doses of corticosteroids for a short time at the start of the reaction, usually prednisone 1–2 mg/kg/day for 3–5 days. However concerns have been raised that they may increase the risk of infection, impair wound healing and other complications, and they have not been proven to have any benefit. They are not effective later in the course of the illness. Carr DR, Houshmand E, Heffernan MP. Approach to the acute, generalized, blistering patient. Semin Cutan Med Surg 2007; 26: 139–46 . PubMed.

Temperature maintenance — as body temperature regulation is impaired, the patient should be in a warm room (30–32C) Skin biopsy is usually required to confirm the clinical diagnosis and to exclude staphylococcal scalded skin syndrome (SSSS) and other generalised rashes with blisters. Plus, if you're willing to shell out a bit more cash over the vanilla model, the PC-011 comes in a Razer Edition as well. Fully integrated with the Synapse 3 lighting software, you can even coordinate it with your other Razer-made peripherals. González-Herrada C, Rodríguez-Martín S, Cachafeiro L et al; PIELenRed Therapeutic Management Working Group. Cyclosporine Use inEpidermal Necrolysis Is Associated with an Important Mortality Reduction:Evidence from Three Different Approaches. J Invest Dermatol. 2017 Oct;137(10):2092–2100. doi: 10.1016/j.jid.2017.05.022. Epub 2017 Jun 17. Review. PubMed PMID: 28634032. PubMed. Case reports and small patient series have reported benefit from active adjuvant treatments delivered during the first 24–48 hours of illness. As SJS/TEN is a rare condition, controlled trials of therapies in large numbers of patients are difficult.

What are the clinical features of SJS/TEN?

SCORTEN is an illness severity score that has been developed to predict mortality in SJS and TEN cases. One point is scored for each of the seven criteria present at the time of admission. The SCORTEN criteria are: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are now believed to be variants of the same condition, distinct from erythema multiforme. SJS/TEN is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss. Using current definitions, it is nearly always caused by medications. Who gets SJS/TEN?

Thalidomide, trialled because of its anti-TNFα effect, increased mortality, and should not be used. How can SJS/TEN be prevented? Blood tests do not help to make the diagnosis but are essential to make sure fluid and vital nutrients have been replaced, to identify complications and to assess prognostic factors (see below). Abnormalities may include: Avoid using adhesive tapes and unnecessary removal of dead skin; leave the blister roof as a ‘biological dressing’.There is then an abrupt onset of a tender/painful red skin rash starting on the trunk and extending rapidly over hours to days onto the face and limbs (but rarely affecting the scalp, palms or soles). The maximum extent is usually reached by four days. SJS/TEN is a rare and unpredictable reaction to a medication. The mechanism has still not been understood and is complex. The kitchen is led by Head Chef Richard Hards who has trained under some of London’s most established chefs. Under Hard’s direction, the food offering in the Bistrot a Vin is likewise ever-changing and seasonal, serving up modern Franco-European fare and is comprised of a small selection of starters, mains, and desserts. The 10 Cases also offers a range of wine-friendly tapas style dishes, cheeses, and charcuterie if you’re after some little nibbles to sip with your wine. Credit: Matthew Hague / The 10 Cases