Solgar DLPA 500 mg (DL-Phenylalanine) Vegetable Capsules - Pack of 50

Product Information

Vitiligo is an autoimmune disease in which cells that make the skin pigment melanin gets destroyed. As a result, melanin content drops and parts of the skin lose color [ 16]. Phenylalanine molecule has 2 different forms, L- and D-phenylalanine, which are “mirror images” with the same structure. As you can see in the image above, they are only differently oriented in space [ 3]. Christianson DW, Mangani S, Shoham G, Lipscomb WN (August 1989). "Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A" (PDF). The Journal of Biological Chemistry. 264 (22): 12849–12853. doi: 10.1016/S0021-9258(18)51564-7. PMID 2568989. It can be viewed as a benzyl group substituted for the methyl group of alanine, or a phenyl group in place of a terminal hydrogen of alanine. This essential amino acid is classified as neutral, and nonpolar because of the inert and hydrophobic nature of the benzyl side chain. The L-isomer is used to biochemically form proteins coded for by DNA. Phenylalanine is a precursor for tyrosine, the monoamine neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), and the skin pigment melanin. It is encoded by the codons UUU and UUC.

The stereoisomer D-phenylalanine (DPA) can be produced by conventional organic synthesis, either as a single enantiomer or as a component of the racemic mixture. It does not participate in protein biosynthesis although it is found in proteins in small amounts - particularly aged proteins and food proteins that have been processed. The biological functions of D-amino acids remain unclear, although D-phenylalanine has pharmacological activity at niacin receptor 2. [16] Broadley KJ (March 2010). "The vascular effects of trace amines and amphetamines". Pharmacology & Therapeutics. 125 (3): 363–375. doi: 10.1016/j.pharmthera.2009.11.005. PMID 19948186. The below doses may not apply to you personally. If your doctor suggests using DLPA, work with them to find the optimal dosage according to your health condition and other factors. Tyrosine is a direct precursor to L-dopa, which converts to dopamine, epinephrine (adrenaline), and norepinephrine.This means that it, and by extension phenylalanine, are needed for energy, pleasure and motivation.Like all amino acids, phenylalanine serves a variety of functions in the body–in this case, most of the notable benefits of phenylalanine are brain-related. DL Phenylalanine Benefits

D-phenylalanine is the synthetic form made in the lab. Your body partly converts it to the L-form or eliminates it via urine, but it also has some specific health effects discussed below [ 6, 7]. By building up your natural endorphin production, DLPA doesn’t just help reduce physical pain – but mental pain as well. If there's one group of people who require a smart drug, it's college students. College-level students frequently participate in demanding courses that require long study hours. Over-the-counter Adderall can help provide the focus and energy it takes to participate in marathon study sessions and improve academic performance. Additionally, the cognitive benefits of these supplements can make it easier for students to retain knowledge and stay focused on project Low-quality clinical evidence suggests that L-phenylalanine and DLPA may help with mild-to-moderate depression. Further research is warranted. Insufficient Evidence: mg a day is a very low dose too; most studies use doses of 500 mg or more, and most DL-phenylalanine supplements are dosed at at least 500 mg. It is likely, in fact, that a higher dosage would have produced better–or faster–results. DLPA For Opiate WithdrawalThis makes sense considering that researchers have found that people struggling with depression often have low levels of phenylalanine, and supplementation significantly elevates their mood (9). While our body can produce many things (including other amino acids), it cannot produce L-phenylalanine or any other essential amino acids.

Joined with other amino acids, L-phenylalanine builds proteins that support the structure and delicate functions of the entire body. According to a handful of small trials, L-phenylalanine may reduce food intake and support fat burning [ 9, 21, 22, 23, 24].

As such, DLPA should only be used by opioid users at the recommendation of a doctor, and must be used with care. DL Phenylalanine Dosage I’ve gathered their comments below and bolded anything that I can personally relate to or I have experienced while taking it: The typical dose is about 1,000 to 2,000 mg DLPA a day, divided into 2 or 3 doses throughout the day. DLPA Potential Side Effects These neurotransmitters are heavily involved in mood, reward, arousal, attention, and other critical processes. As with other amino acids, DLPA may interfere with the effects of levodopa, a drug commonly used to treat Parkinson’s disease. Don’t combine the two.