Ubiquinone Coenzyme Q10 300mg Softgel Capsules, 120 Super Strength Vegan Friendly Naturally Fermented High Absorption CoQ10 Capsules Made in The UK to GMP Standards – by The Intelligent Health

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Cardiovascular disease is the leading cause of death worldwide [ 1]. Hyperlipidemia is a major risk factor for coronary artery disease (CAD). A higher level of low density lipoprotein-cholesterol (LDL-C) can increase the incidence of CAD [ 2]. The 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-Co A reductase) inhibitors (statins) have been the most popular drugs for reducing the level of LDL-C, and they are an established strategy for decreasing the frequency of CAD events [ 3]. Coenzyme Q10 (also called ubiquinone) is a lipid-soluble benzoquinone that has 10 isoprenyl units in its side chain and is a key component of the mitochondrial respiratory chain for adenosine triphosphate synthesis [ 4, 5]. Statins can decrease the synthesis of cholesterol and other molecules downstream of mevalonate. Mevalonate is a precursor of coenzyme Q10. Statins not only lower the blood cholesterol but also lower the level of coenzyme Q10 [ 6- 9]. A disease that causes curved, painful erections ( Peyronie disease). Research shows that taking coenzyme Q10 improves erectile function in men with painful erections. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005; 111:1448–1454. doi: 10.1161/01.CIR.0000158483.13093.9D. [ PubMed] [ CrossRef] [ Google Scholar] Knott A, Achterberg V, Smuda C, et al. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects. BioFactors. 2015;41(6):383-390. doi:10.1002/biof.1239 Skarlovnik A, Janić M, Lunder M, Turk M, Šabovič M. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Med Sci Monit. 2014;20:2183-2188. doi:10.12659/MSM.890777

Thankfully, supplements can raise your levels of CoQ10 and may even improve your overall quality of life. It’s not clear whether low levels of co-Q10 are a result of, or the trigger for, these conditions. 21Those with heart conditions, such as heart failure and angina, may benefit from taking a CoQ10 supplement. Although not all side effects are known, Coenzyme Q10 is thought to be likely safe for most adults when used as directed. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. No serious side effects of co-Q10 have been reported, but mild side effects include insomnia and digestive problems.

Coenzyme Q10 (PDQ)-Health Professional Version. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/cam/patient/coenzyme-q10-pdq#section/all. Accessed Oct. 18, 2020. Regarding the safety of statins therapy and its combination with placebo or coenzyme Q10 in the present study, there were no clinically significant changes in the subjects’ vital signs, serum chemical values, or hematological values, and there were no serious adverse events, no complaints of myalgia or muscle weakness, and no withdrawals due to adverse events. Thus, coenzyme Q10 at a dose of 300mg/d is safe for co-administration with statins therapy.However, other studies have shown no effect, emphasizing the need for more research on this topic ( 12).

Sazali S, Badrin S, Norhayati MN, Idris NS. Coenzyme Q10 supplementation for prophylaxis in adult patients with migraine—a meta-analysis. BMJ Open. 2021;11(1):e039358. doi:10.1136/bmjopen-2020-039358 CoQ10 supplements aren’t necessary for everyone.“If you have a balanced diet, and if you’re young and healthy, you probably have enough CoQ10 in your body,” Peart says. “Supplements can be helpful if there’s a CoQ10 deficiency.”Although studies about the effectiveness of CoQ10 have drawn different conclusions, supplements are generally thought to be helpful for a few specific conditions. MigrainesOther causes of CoQ10 depletion include statin medication use, heart disease, nutrient deficiencies, genetic mutations, oxidative stress and cancer ( 6). A 2018 meta-analysis reexamined five studies investigating the use of CoQ10 supplements for migraines. The meta-analysis concluded that CoQ10 is more effective than a placebo at reducing the duration of migraines. However, CoQ10 did not appear to affect migraine severity or frequency. Protecting against age-related diseases Sifuentes-Franco S, et al. (2022). Antioxidant and anti-inflammatory effects of Coenzyme Q10 supplementation on infectious diseases.

As an antioxidant, CoQ10 helps to shield your skin from irritants and damage from external factors. Drobnic F, et al. (2022). Coenzyme Q 10 supplementation and its impact on exercise and sport performance in humans: A recovery or a performance-enhancing molecule? Nerve pain in people with diabetes ( diabetic neuropathy). Research shows that taking coenzyme Q10 improves nerve damage and nerve pain in people with nerve damage caused by diabetes.For people taking statin medications, the typical dosage recommendation for CoQ10 is 30–200 mg per day ( 13). Heart Disease