276°
Posted 20 hours ago

C.K 492001 Electricians Scissors

£8.995£17.99Clearance
ZTS2023's avatar
Shared by
ZTS2023
Joined in 2023
82
63

About this deal

Gross SD, Simerly C, Schatten G, Anderson RA: A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte. J Cell Sci. 1997, 110 (Pt 2): 3083-3090. Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E, Miller DM: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat Chem Biol. 2010, 6: 829-836. 10.1038/nchembio.453 Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF, Meek DW: p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene. 1997, 15: 1727-1736. 10.1038/sj.onc.1201541 Gross SD, Anderson RA: Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal. 1998, 10: 699-711. 10.1016/S0898-6568(98)00042-4 Yu DH, Macdonald J, Liu G, Lee AS, Ly M, Davis T, Ke N, Zhou D, Wong Staal F, Li QX: Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS One. 2008, 3: e3951- 10.1371/journal.pone.0003951

Izeradjene K, Douglas L, Delaney AB, Houghton JA: Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex. Cancer Res. 2004, 64: 8036-8044. 10.1158/0008-5472.CAN-04-0762 Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh-Hain JA, Ng S-K, Choi P-W, Fong W-P, Agar NYR, Welch WR, Berkowitz RS, Ng S-W: Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med. 2012, 4: 952-963. 10.1002/emmm.201101094 Sinnberg T, Menzel M, Ewerth D, Sauer B, Schwarz M, Schaller M, Garbe C, Schittek B: β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One. 2011, 6: e23429- 10.1371/journal.pone.0023429 Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT: Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A. 2009, 106: 1193-1198. 10.1073/pnas.0811902106Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y: A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell. 2013, 24: 242-256. 10.1016/j.ccr.2013.06.005 Waugh MG, Challiss RA, Berstein G, Nahorski SR, Tobin AB: Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors. Biochem J. 1999, 338 (Pt 1): 175-183.

Li G, Yin H, Kuret J: Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. J Biol Chem. 2004, 279: 15938-15945. 10.1074/jbc.M314116200 Tsai I-C, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM: Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer. 2007, 120: 1005-1012. Fuja TJ, Lin F, Osann KE, Bryant PJ: Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res. 2004, 64: 942-951. 10.1158/0008-5472.CAN-03-2100

Order Approval

Price MA, Kalderon D: Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell. 2002, 108: 823-835. 10.1016/S0092-8674(02)00664-5

Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N: ntegrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013, 6: pl1- Wang Y, Hu L, Tong X, Ye X: Casein kinase 1γ1 inhibits the RIG-I/TLR signaling pathway through phosphorylating p65 and promoting its degradation. J Immunol. 2014, 192: 1855-1861. 10.4049/jimmunol.1302552 Sarasqueta AF, Forte G, Corver WE, de Miranda NF, Ruano D, van Eijk R, Oosting J, Tollenaar RAEM, van Wezel T, Morreau H: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC Cancer. 2013, 13: 277- 10.1186/1471-2407-13-277 Shen T, Liu Y, Cseresnyés Z, Hawkins A, Randall WR, Schneider MF: Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Mol Biol Cell. 2006, 17: 1570-1582. 10.1091/mbc.E05-08-0780

Tobin AB: Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation. Trends Pharmacol Sci. 2002, 23: 337-343. 10.1016/S0165-6147(02)02043-6 Toyoshima M, Howie HL, Imakura M, Walsh RM, Annis JE, Chang AN, Frazier J, Chau BN, Loboda A, Linsley PS, Cleary MA, Park JR, Grandori C: Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc Natl Acad Sci U S A. 2012, 109: 9545-9550. 10.1073/pnas.1121119109 C.K tools are engineered to offer leading performance, durability, accuracy and strength, all of which are key requirements for professional results.

Asda Great Deal

Free UK shipping. 15 day free returns.
Community Updates
*So you can easily identify outgoing links on our site, we've marked them with an "*" symbol. Links on our site are monetised, but this never affects which deals get posted. Find more info in our FAQs and About Us page.
New Comment