We will analyse all data on an intention-to-treat basis. Data of patients who are lost to follow-up will be included in their randomised group: Betaine ( trimethyl glycine) to compensate for a possible defect of the enzyme CHDH (choline-dehydrogenase) Although Impryl cannot increase your ovarian reserve, it can maximise the quality of eggs available.

Like I said nothing had changed in our diet and our physical relationship was still the same from before we started ttc… which is a long time! The present invention relates to pharmaceutical, dietary and/or food compositions, preferably dietary supplements, exerting the ability to activate the endogenous antioxidant system by feeding essential micronutrients to both the one carbon cycle and the trans-sulfuration pathway so to achieve effective oxy-redox homeostasis together with an improved energy balance and healthy processes of cell growth and differentiation including DNA methylation and epigenetic regulation.

Live birth rate (beyond 24 weeks, defined as the birth of a living child) within study period of 15 months.

Studies have shown a benefit for women with a diminished ovarian reserve. This evidence comes from a number of small but reasonably powered studies. Impryl is the benchmark of the antioxidants support. According to the new strategy, instead of using antioxidant substances, that act only on a limited number of sensitive pathways and that may generate negative counter effects, Impryl leverage on the physiologic antioxidant system to achieve a better oxy-redox balance within the control of the natural cellular homeostasis. This approach is resulting in clinical improvements that appeared impossible by using traditional antioxidant molecules. In addition Impryl contains only substances normally present in the diet for a easy and safe use with no limits of duration. Infertility can be a lonely, all-consuming place to be. It can affect every aspect of your life. You may have been trying to get pregnant for a while, you may need help trying to conceive, you may be going through fertility treatment and want to optimise your fertility or you may have only just decided that you want to get pregnant. Whatever the case, we want to reassure you that you aren’t alone — we provide information and products to support your fertility. Inofolic ® Alpha and Impryl ® are fertility supplements that focus on helping both the sperm and the egg to be of optimal quality to help you enjoy a healthy pregnancy. Every cell contains at least one powerhouse, these are called mitochondria, which produce all the energy the cell needs to function. Producing energy creates waste toxins as a by-product, these are called ROS (Reactive Oxygen Species). There must be a certain degree of probability that the event is a harmful and an undesirable reaction to the medicinal product under investigation, regardless of the administered dose.Folic acid in its methylated, active form ( methylfolate) to compensate for a possible defect of the enzyme MTHFR (Methylene-Tetra-Hydro-Folate-Reductase) Impryl contains activated micronutrients that help your body to produce Glutathione (GSH), the body’s natural antioxidant, and ensures that GSH is produced only when and where it is required, thus delivering balanced support. The micronutrients within Impryl are proven to help prevent both DNA fragmentation and DNA decondensation. 2. Energy Support What is Energy Support? Think about how the engine of your car produces power but also waste. The car uses a catalytic converter to ensure that toxins are not released into the surrounding environment. This is similar to the mitochondria (the engine) in a cell producing energy and waste. The GSH (the catalytic converter) removes the waste before it can be released into the rest of the cell (the environment) and do damage. What does this have to do with having a baby? We aimed to recruit 1200 male participants as a part of an infertile couple, based on the following data and power calculation.

We’re surely not out of the woods yet with my wife as we undergo an IVF cycle but the doctors said my semen quality was absolutely top-notch. The remarkable effectiveness of the antioxidant activation on the one hand and the respect for the metabolic physiology on the other, make Impryl the ideal support for reproduction. Gametogenesis is, among the physiological functions, the most sensitive to a perfect metabolic balance. This is currently defined as pre-conceptional support, i.e. a supplementation of both partners from at least three months before conception. The positive effects will concern not only the chances of conceiving but also the probability of having a serene pregnancy and a healthy baby. For comprehensive information see the preconception care advices from the World Health Organization (WHO). Competing interests The study is conducted by the department of gynaecology and obstetrics of the Radboudumc. As stated above in the funding section, an unrestricted grant from Goodlife Pharma B.V. was provided for the conduct of the trial. The protocol and all protocol modifications are approved by the local METC at the Radboud University Medical Centre and by the national Central Committee on Research Involving Human Subjects with protocol ID NL61414.091.17. The remaining SUSARs are recorded in an overview list (line listing) that will be submitted once every half year to the METC. This line listing provides an overview of all SUSARs from the study medicine, accompanied by a brief report highlighting the main points of concern. The expedited reporting of SUSARs through the web portal Eudravigilance or ToetsingOnline is sufficient as notification to the competent authority.Funding The study is supported by an unrestricted grant from Goodlife Pharma BV. This company has developed and marketed Impryl. The grant is unrestricted in means that the funder did not have any role in the design of the study, collection, analysis and/or interpretation of data. The investigators have full access to the data and have the right to publish these data separate and apart from any sponsor. I had been diagnosed with asthenozoospermia (not enough motility) and my volume was consistently lower than average. I wanted to post this because I felt devastated after the first analysis. Every single one of my husband’s parameters, including count, has improved drastically in % terms. I have no doubt these tablets played a part in helping with conceiving and I can’t recommend enough. We had a lot of dark day thinking this may never happen again for us and while I cant promise these pills are the magic ingredient, they certainly helped us and I will be forever grateful that we took the advice and tried Impryl." At least two semen analyses will be performed at two time points in this study: the first semen analysis will be performed during diagnostic workup (standard care and analysis according to WHO criteria 37) and the second one after approximately 3 months of using study medication for participants having the IUI or IVF/ICSI treatment. We decided not to perform a second semen analysis in the EM group due to the fact that they present with normal semen parameters at intake, and we want to avoid the burden of an extra visit.

Put simply, this means supporting the body’s metabolism to ensure it is in the optimal state possible for producing sperm – and the sperm that is produced is of the best possible quality. It also supports the production of good quality eggs in women. If you have PCOS you probably have a better chance of absorbing myo-inositol into the body when taking this combination. It also includes the essential folic-acid required to reduce neural tubal defects in developing babies. PCOS (polycystic ovary syndrome) affects 1 in 10 women in the UK. It can have a significant effect on women’s fertility, through irregular or absent periods, impacting ovulation, with only 20% of PCOS women ovulating each month, even if some have seemingly regular periods. Women with PCOS are more likely to have poorer egg quality, which may be a result of overexposure to male hormones such as testosterone. Inofolic ® Alpha is a supplement that could help you – with little or no side effects. I got Impryl for my partner as he has low sperm count and morph (2%). He has been taking this for over 3 months. I have been taking inofolic Alpha for nearly 2 months for my pcos. We have been trying ttc for over 5 years now. I only have 2-3 periods a year. I was diagnosed with pcos at 13 and I have over 60 cysts on the ovaries. I’m 28 and my partner is 30 this year. We changed nothing in our routine accept changing our vitmains to Impryl and inofolic alpha.Keep your testicles cool! Normal sperm production occurs just below normal body temperature, which is why the testes are outside the body. Avoid sitting in hot showers or baths or with your laptop on your knees for long periods, wear looser clothing, walk around and go outside when you can. Impryl’s unique balance of micronutrients prevents DNA fragmentation without causing DNA de-condensation. DNA fragmentation is the ‘snipping up’ of DNA in the sperm head, which can contribute towards difficulties in conceiving and/or miscarriage. DNA fragmentation is often treated with strong anti-oxidants such as Vitamin C, Vitamin E, Selenium, CoQ10, Vitamin A and Carotenoids. However, we now know that although they might prevent DNA fragmentation, these strong anti-oxidants can then cause DNA de-condensation, which is the unravelling of the DNA in the sperm head, meaning that conception is not possible at all. Fertility Family is part of Health Medica, a UK healthcare company. Our range of high quality products is recommended by fertility specialists across the UK. Read more about us. Patients who are lost to follow-up during the treatment period are considered not to have achieved a pregnancy.