There may be a risk the medicines do not mix, which could stop either from working properly or increase the risk of side effects. Paediatric population: The half-life of cetirizine was about 6 hours in children of 6-12 years and 5 hours in children 2-6 years. In infants and toddlers aged 6 to 24 months, it is reduced to 3.1 hours. Allergy skin tests are inhibited by antihistamines and a wash-out period (of 3 days) is required before performing them.

Take your medicine as advised by the pharmacist or doctor, or as described in the leaflet that comes with it. Try not to drink alcohol while taking an antihistamine, particularly if it's a type that makes you drowsy, as it can increase the chances of it making you feel sleepy. Renal impairment: The pharmacokinetics of the drug was similar in patients with mild impairment (creatinine clearance higher than 40 ml/min) and healthy volunteers. Patients with moderate renal impairment had a 3-fold increase in half-life and 70 % decrease in clearance compared to healthy volunteers.

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second-generation antihistamines (also known as non-sedating antihistamines because they don't tend to cause drowsiness, although they may do so in some people). headaches – make sure you rest and drink plenty of fluids. It's best not to drink too much alcohol. Ask your pharmacist to recommend a painkiller for your headaches, but they usually go away after the first week of taking cetirizine. Talk to your doctor if your headaches last longer than a week or are severe. If you are having an operation, or any treatment or tests (particularly if it is to test for an allergy), make sure you say that you are taking an antihistamine. The extent of absorption of cetirizine is not reduced with food, although the rate of absorption is decreased. The extent of bioavailability is similar when cetirizine is given as solutions, capsules or tablets. Response to allergy skin tests are inhibited by antihistamines and a wash-out period (of 3 days) is required before performing them.

Own-brand or generic antihistamines are typically the cheapest option, often at least half the price of big-brand versions. Examples of medicines that could cause problems if taken with antihistamines include some types of: how long to take it for – some types can be used for a long time, but some are only recommended for a few days Treating a chronic itchy nettle-type rash where the cause isn't known (chronic idiopathic urticaria).Some cases of memory loss and/or impairment have also been reported. In very rare casespeople have thought about committing suicideand if you feel this way then stop taking thetablets and see your doctor If you drink alcohol while you are on cetirizine, be aware of its effects on you and do not drink more than moderate amounts. Alcohol can increase the risk of side-effects from antihistamines. The other ingredients are: lactosemonohydrate, maize starch, pregelatinisedstarch, purified talc, magnesium stearate,hypromellose, titanium dioxide (E171) andmacrogol. Cetirizine works by preventing the actions of histamine - a substance produced by the body when it reacts to a foreign substance such as pollen or pet fur (an allergen). Histamine acts on histamine receptors, causing a chain reaction that results in allergic symptoms.

Sedating antihistamines (see explanation below) also act in the brain and spinal cord, and on other receptors. This makes some of them also useful for: One method that's suitable for some people is immunotherapy treatment. This involves gradually introducing you to small amounts of your particular allergen and monitoring your reaction in a controlled environment. you have predisposition factors of urinaryretention (e.g. spinal cord lesion, prostatichyperplasia) as cetirizine increases the riskof urinary retention. The advice varies depending on the exact medicine you're taking. If you're not sure how to take your medicine, ask a pharmacist. Side effects of antihistamines

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In mice, rats, and rabbits, cetirizine was not teratogenic at oral doses up to 96, 225, and 135 mg/kg, respectively (approximately 40, 180 and 220 times the maximum recommended daily oral dose in adults). There are no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, cetirizine should be used in pregnancy only if clearly needed . Instances of abnormal hepatic function with elevated hepatic enzymes accompanied by elevated bilirubin have been reported. Mostly this resolves upon discontinuation of the treatment with cetirizine dihydrochloride. Histamine is normally released when your body detects something harmful, such as an infection. It causes blood vessels to expand and the skin to swell, which helps protect the body.

If you have ongoing hay fever symptoms that aren't relieved by any of the usual treatments, your GP may refer you to an allergy specialist for further investigation and treatment. Cetirizine comes as tablets and capsules (10mg) and as a liquid medicine (labelled either 5mg/5ml or 1mg/1ml). Most hay fever medication works best when you take it before the pollen is in the air and your symptoms develop.Patients with moderate to severe renal impairment: There are no data to document the efficacy/safety ratio in patients with renal impairment. Since cetirizine is mainly excreted via renal route , in cases no alternative treatment can be used, the dosing intervals must be individualized according to renal function. Refer to the following table and adjust the dose as indicated. To use this dosing table, an estimate of the patient's creatinine clearance (CL cr) in ml/min is needed. The CL cr (ml/min) may be estimated from serum creatinine (mg/dl) determination using the following formula: If your hay fever symptoms are really bad, you may occasionally need short-term relief. If this is the case, your GP may prescribe a short course of steroid tablets lasting between five to 10 days. If you have kidney problems you should talk to your doctor or pharmacist for advice beforetaking these tablets as a lower dose may berequired. Rare: hepatic function abnormal (increased transaminases, alkaline phosphatase, γ-GT and bilirubin)