Szajewska H, Kolodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther 2015;42:793-801. [ PubMed abstract] The review also found that multistrain probiotics used for at least 8 weeks were the most effective for improving IBS symptoms. But there's little evidence to support many health claims made about them. For example, there's no evidence to suggest that probiotics can help treat eczema.

Sanders ME. Probiotics in 2015: their scope and use. J Clin Gastroenterol 2015;49 Suppl 1:S2-6. [ PubMed abstract] In a systematic review and meta-analysis of 21 RCTs in a total of 4,780 participants, treatment with Saccharomyces boulardii compared with placebo or no treatment reduced the risk of AAD in 3,114 adults treated with antibiotics from 17.4% to 8.2% [ 29]. In the 1,653 children in this study, Saccharomyces boulardii reduced the risk from 20.9% to 8.8%. Various doses of Saccharomyces boulardii were tested, and no clear dose-dependent effects were observed.Numerous probiotic studies have evaluated the effects of various species and strains of bacteria on the prevention of atopic dermatitis, and several meta-analyses have synthesized the findings of these studies. These studies and meta-analyses show that exposure to probiotics during pregnancy and in early infancy might reduce the risk of developing atopic dermatitis in children. For example, a 2018 meta-analysis included 27 randomized controlled trials (RCTs) and one controlled cohort study in a total of 6,907 infants and children exposed to probiotics in utero for 2 weeks to 7 months (via maternal oral supplementation) and/or by oral administration to the infants after birth for 2 to 13 months [ 13]. Between age 6 months and 9 years, probiotic treatment with single strains or mixtures that included Lactobacillus, Bifidobacterium, and Propionibacterium strains significantly reduced the risk of atopic dermatitis from 34.7% in the control group to 28.5% in the probiotic group. Several meta-analyses have assessed the role of probiotics in patients with IBS [ 42-46]. Most have found that probiotics have a positive, although modest, beneficial effect. For example, a meta-analysis of 23 RCTs in a total of 2,575 patients found that, overall, probiotics reduced the risk that IBS symptoms would persist or not improve by 21% [ 42]. Various species and strains of probiotics had beneficial effects on global IBS symptoms, abdominal pain, bloating, and flatulence scores, but the quality of the studies was low. Some combinations of probiotics were superior to individual strains in this analysis, but no specific combination was superior to another. A second meta-analysis of 15 RCTs in a total of 1,793 patients with IBS found that probiotics reduced overall symptoms and abdominal pain more than placebo after 8 to 10 weeks of therapy; in children, these supplements also improved mucosal barrier function [ 43].

The product contains Lab4, the most researched group of friendly bacteria in the UK, along with Lactobacillus plantarum, an additional strain of live bacteria to provide a high-strength multi-strain product – with a total of 50 billion live bacteria per capsule. May promote immune health: Evidence supports the role of probiotic supplements in maintaining immune health. Several studies suggest that probiotics may enhance immune function in certain populations, but more research is needed.

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But for most people, probiotics appear to be safe. If you want to try them, and you have a healthy immune system, they shouldn't cause any unpleasant side effects. Issues to be aware of Individuals receiving inpatient care are at significantly greater risk of developing AAD than individuals receiving outpatient care. Similarly, children younger than 2 years and seniors older than 65 years are at greater risk of developing AAD than other children and adults. Some antibiotics (e.g., erythromycin and penicillin) are associated with AAD more often than others [ 25, 26].