The very best way to obtain allicin is from eating fresh garlic that has been crushed or sliced. Fresh, uncooked garlic should be crushed, sliced, or chewed to maximize allicin production.

Allicin Benefits, Side Effects, Supplements, Dosage and More Allicin Benefits, Side Effects, Supplements, Dosage and More

Khuda-Bukhsh AR, Das S, Saha SK. Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways. Nutr Cancer. 2014;66(2):194-205. doi:10.1080/01635581.2014.864420 Mondal A, Banerjee S, Bose S, et al. Garlic constituents for cancer prevention and therapy: from phytochemistry to novel formulations. Pharmacol Res. 2021;105837. doi:10.1016/j.phrs.2021.105837 It’s one reason why eating garlic is linked to widespread health benefits, like cardiovascular health, better cognition, resistance to infection and other anti-aging effects, Ried K. Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. Exp Ther Med. 2020;19(2):1472-1478. doi:10.3892/etm.2019.8374Song K, Milner JA. The influence of heating on the anticancer properties of garlic. J Nutr. 2001;131(3s):1054S-7S. doi:10.1093/jn/131.3.1054S

Allicin Max | Garlic Capsules to Support the Immune System

In the manufacturing process, a special flood reaction system using only water is able to produce large quantities of stabilised allicin. The liquid is then carefully dried, under controlled conditions, to maintain its potency. This sophisticated process has for the first time allowed us to capture garlic's active component in a form that can be used by the body. Isolation and testing of the organosulfur compounds from garlic for antimicrobial activity was carried out in the 1940s [ 9]. Neither DADS, directly formed by the decomposition of allicin, nor the diallylpolysulfanes showed any remarkable antimicrobial activity, unless used in very high concentrations. Koch and Lawson [ 5] determined the minimal concentration of organosulfur compounds found in crushed garlic needed to inhibit the growth of Escherichia coli and Staphylococcus aureus. According to their results, approximately 35× more DADS (6.15 mM) was needed to inhibit the growth of these two bacteria compared to allicin (0.17 mM). Bat-Chen and co-workers, for instance, showed that Nrf2 is involved in allicin-induced apoptosis [ 106]. This reveals the “Janus face” of Nrf2 [ 107]: While Nrf2 is mostly described as an anti-apoptotic factor regulating the expression of anti-apoptotic proteins of the Bcl-2 family like Bcl-2 and Bcl-xL [ 108, 109], Nrf2 also seems to have a pro-apoptotic function under certain circumstances ( ibid.). Also the ERK1/2 map kinases were shown to be influenced by allicin in immune cells; these kinases are also important for apoptosis induction by allicin [ 103, 110]. Allowing crushed garlic to stand for 10 minutes before being cooked may help increase levels and some biological activity. However, it’s debatable how well this compound can withstand its journey through the gastrointestinal tract once eaten.

In the same way that allicin can protect garlic from threats, it can also protect us. Numerous studies have been performed on allicin, particularly for treating bacterial, fungal, and viral infections.

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There are two main classes of organosulfur compounds found in whole garlic cloves: L-cysteine sulfoxides and γ-glutamyl-L-cysteine peptides. How allicin affects cancer cells has been examined at the molecular level. It became clear that the induction of apoptosis was crucial for the anti-cancer effect of allicin. As discussed in the yeast system (see above), allicin also causes a redox-shift in human cell cultures [ 103]. This leads to the execution of cell death, both in a caspase-dependent [ 104] and caspase-independent manner [ 105]. Beside caspase activity, the apoptosis inducing factor (AIF), which contributes to the apoptotic DNA-laddering, is involved in allicin-induced cell death ( ibid.). Aged garlic extract is the only water-based garlic supplement, which makes it more bioavailable than most other forms. Aged garlic is also a popular form of garlic to use for supplementation since it does not have a strong garlic scent.What are the benefits of allicin for heart health? Overall, scientific studies have provided conflicting results. Another central regulator of a coordinated immune-response is the TNFα cytokine [ 97]. Impairment of TNFα secretion massively influences the regulation of the immune-response. For that reason it is interesting that allicin inhibits the release of TNFα-dependent pro-inflammatory cytokines in intestinal epithelia [ 98]. This, however, reflects an effect of allicin on factors downstream of TNFα. Since TNFα is mainly secreted by macrophages [ 99], the effect of allicin on macrophages was examined with respect to how allicin influences the expression of TNFα itself. It is interesting that a stimulation of macrophages by lipopolysaccharide (LPS) after a pre-incubation in the presence of allicin enhances the activity of the TNFα promoter, suggesting a TNFα-triggering role for allicin in LPS-stimulated cells [ 100]. Furthermore, allicin inhibits phosphatase-activity, correlating with an enhanced phosphorylation of ERK1/2 ( ibid.), which is a central component of the signalling cascade transferring extracellular signals into intracellular signalling cascades. Furthermore, the release of Reactive Nitrogen Species (RNS) by LPS-stimulated macrophages was suppressed by allicin [ 100, 101]. According to the Linus Pauling Institute, the half-life of allicin in crushed garlic is only 2.5 days. So, it is no wonder that studies have shown that garlic supplements contain no allicin. 9 Alare K, Alare T. Open Acc J of Toxicol Review of Toxicity of Allicin From Garlic. Open Acc J of Toxicol. 2020;4(5). doi:10.19080/OAJT.2020.04.555647

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Choo S, Chin VK, Wong EH, et al. Review: antimicrobial properties of allicin used alone or in combination with other medications. Folia Microbiol (Praha). 2020;65(3):451-465. doi:10.1007/s12223-020-00786-5There are a lot of reasons not to take antibiotics, like antibiotic resistance or their high cost. But, for me, the biggest risk of antibiotics is that they disrupt your gut flora. One example for the oxidation of a redox-sensitive transcription factor by the electrophile allicin is the Nrf2/Keap1 system that regulates the expression of various anti-oxidative enzymes (among others of glutathione-biosynthesis). The fact that allicin can induce the Nrf2/Keap1 system has been shown in various studies [ 79, 80]. It needs to be mentioned that the activation of Nrf2 by allicin is not only important in the context of cardiovascular diseases, but also for various other health related events like neurodegenerative diseases. In that context it was shown that allicin attenuates age-related cognitive and memory deficits by activating the Nrf2-system [ 80]. Unlike other allicin supplements, Allimed is made from stabilized allicin known as Allisure. Allisure won’t be broken down by GI acids and can actually be absorbed into the body. Allimed has been around for over a decade now and has been used in numerous tests and achieved great results.