If you accidentally get cream in your eye, wash out thoroughly with warm water. Consult your doctor if you are concerned. If you are allergic to Aciclovir, valaciclovir,propylene glycol or any other ingredients of thepreparation (see section 6 for a complete list ofingredients). Tell your doctor if you are pregnant or planning to become pregnant. A small amount of this drug doespass into breast milk. If you are breast-feeding or areplanningto breast-feed your baby tel I your doctor. Driving and using machines: Two metabolites could be identified in the urine of patients with normal renal function after single dosing with 14C-Aciclovir: 9-carboxymethoxymethylguanine (2-14% of an administered dose) and 8-hydroxy-9-(2-hydroxyethoxymethyl)guanine(<0.2% of a dose). Subjects with normal renal function eliminate 62-91% of an aciclovir dose unchanged and 9-14% as 9-carboxymethoxymethylguanine via the kidneys.

Rabbits had 1, 3 or 6% aciclovir cream in a white petrolatum vehicle introduced directly into both eyes 5 times daily at 90-minute intervals for 3 weeks. Neither autopsy nor inspection nor histological examination revealed any pathological changes in the rabbit eyes. You should apply Lipsore 5% w/w Cream to theinfected area 5 times each day, at intervals of about4 hours, nighttime application can be omitted. Aciclovir is an antiviral cream used to treat herpes simplex. Herpes simplex virus or HSV for short is a highly contagious virus that once contracted, usually before the age of 10, lies inactive within the body. HSV can then become active from time to time, usually if you are run down. HSV is very common it is believed that 7 in 10 people carry the virus but for some people it might remain inactive.

Dose adjustment of IV for patients with acute or chronic renal impairment, based on Creatinine Clearance, Cr Cl (mL/min/1.73 m2): Tell your doctor or pharmacist before use ifyou are taking any regular medication on prescription or over the counter products. Aciclovir is predominantly eliminated via the kidneys, primarily by glomerular filtration and to a lesser extent by tubular secretion.

Moisturize your lips with a hydrating lip balm immediately after exfoliating. [15] X Expert Source Tymia Yvette No specific studies of topical aciclovir have been carried out in pregnant women or nursing mothers. Use the cream for up to 5 days. If the infection has not healed after this time, you can continue to use it for a further 5 days. Aciclovir is a pharmacologically inactive substance. After penetration into cells which are infected with herpes simplex virus types I and (HSV I & HSV II) or varicella-zoster virus (VSV), aciclovir is converted into a virostatic agent. The conversion of aciclovir is catalysed by viral HSV- or VZV- thymidine kinase. Human thymidine kinase does not use aciclovir effectively as a substrate, hence the toxicity to mammalian host cells is low.

Lipsore 5%

Continue treatment for 4 days. If your cold sores haven’t healed after this time, you can use the cream for up to 10 days in total. Lipsore Cream is used for the treatment of cold sores on the lips and face. It contains aciclovir, which belongs to a group of medicines called antivirals. Lipsore Cream helps to slow the growth of the virus, and speeds up the healing of cold sore blisters. What are Cold sores? Wash your hands again. Herpes simplex isinfectious and you should try to avoid touching theinfected skin with your hands or with towels, etc.to prevent spreadingthe infection. Lipsore 5% w/w Cream is used to treat cold sores of the lips and face caused by the herpes simplex virus.Aciclovir has been shown to speed up the healing ofcold sore blisters if it is used soon enough. 2. Before you use Lipsore 5% w/w Cream

Aciclovir is an antiviral agent which is highly active in vitro against herpes simplex virus (HSV) types 1 and 2 toxicity to mammalian host cells is low. Keep Lipsore 5% w/w Cream in its original container and store at a temperature below 25°C but do notrefrigerate or freeze. 6. Further informationWhat the cream contains: Vial containing 250 mg Lipsore 5% will be reconstituted with 50 ml infusion solution and vial containing 500 mg Lipsore 5% will be reconstituted with 100 ml infusion solution. Besides, Vial containing 1 gm Lipsore 5% will be reconstituted with 250 ml infusion solution. 10 ml of the infusion solution will be added to the vial containing 250 mg, 500 mg and 1 gm Lipsore 5%. Shake well and transfer the required amount of solution to the infusion container. The final concentration of Lipsore 5% will be not more than 5 mg/ml. To work at its best, Lipsore 5% w/wCream shouldbe started as soon as possible after the firstsymptoms of infection appear. Best used at the time of the first tingling sensation but will also reduce the healing time after the blister has formed.

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If you have a weak immune system, for exampleafter chemotherapy or radiotherapy or due toimmune deficiency disease or following transplantsurgery. Consult your doctor first if you have aninfection. In internationally accepted standard tests the systemic administration of Aciclovir did not produce embryotoxic or teratogenic effects in rabbits, rats or mice.

The total daily dosage of Lipsore 5% should be based on the type or severity of infection and given in equally divided doses based on consideration of degree of susceptibility of the pathogens, renal function and body-weight. If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects notlisted in this leaflet. You can also report side effectsdirectly via the yellow card scheme at"htt p://www. mh ra.gov. uk/ye 11owcard 11. The required dose of Lipsore 5% IV should be administered by slow intravenous infusion over a one-hour period. As the aciclovir plasma concentrations following topical application are below the limit of detection, no pharmacokinetic studies are available on topical aciclovir. Therefore, the following data is based on the data after oral or intravenous administration. If your skin infection does not get better after 10days of treatment or gets worse at any time tellyour doctor as soon as possible. If you use more Lipsore 5% w/w Cream than you should:

Pregnancy

Please note that parcels weighing over 2kg may be sent via courier due to Royal Mail weight restrictions. By reporting side effects you can help provide more information on the safety of this medicine. 5. How to store Lipsore 5% w/w Cream Keep out of the sight and reach of children. Aciclovir works by preventing the virus from multiplying and spreading so helping the immune system to fight it off. This means it will help the healing process of current sores and prevent new ones from developing. Aciclovir will not eliminate the herpes simplex virus or prevent future outbreaks of cold sores occurring. It also won’t stop you spreading the virus to others. Key features