Shen H. Y., Zhao H. H., Yang J., Zhao J., Yan L., Chou L. J., Song H. L., New J. Chem., 2022, 46, 3095 Lang R., Du X. R., Huang Y. K., Jiang X. Z., Zhang Q., Guo Y. L., Liu K. P., Qiao B. T., Wang A. Q., Zhang T., Chem. Rev., 2020, 120, 11986 Xu C, Webb WW (1996) Measurement of two-photon excitation cross sections of molecular fluorophores with data from 690 to 1050 nm. J Opt Soc Am B 13:481–491 Wunsch H, Angus DC, Harrison DA, et al. Variation in critical care services across North America and Western Europe. Crit Care Med. 2008;36:2787–93. An IBM 2285 Display Copier could be attached to the 2250 to provide 8½ by 11inch hard copy of the display contents under operator control.

Lu G., Li S. Z., Guo Z., Farha O. K., Hauser B. G., Qi X. Y., Wang Y., Wang X., Han S. Y., Liu X. G., DuChene J. S., Zhang H., Zhang Q. C., Chen X. D., Ma J., Loo S. C. J., Wei W. D., Yang Y. H., Hupp J. T., Huo F., Nat. Chem., 2012, 4, 310 Sinha SS, Mitra RK, Pal SK (2008) Temperature-dependent simultaneous ligand binding in human serum albumin. J Phys Chem B 112:4884–4891 Peddie, Jon (2013-06-13). The History of Visual Magic in Computers: How Beautiful Images are Made in CAD, 3D, VR and AR. Springer Science & Business Media. ISBN 978-1-4471-4932-3. Xia C., Qiu Y. R., Xia Y., Zhu P., King G., Zhang X., Wu Z. Y., Kim J. Y., Cullen D. A., Zheng D. X., Li P., Shakouri M., Heredia E., Cui P. X., Alshareef H. N., Hu Y. F., Wang H. T., Nat. Chem., 2021, 13, 887

Meng D. L., Zhang M. D., Si D. H., Mao M. J., Hou Y., Huang Y. B., Cao R., Angew. Chem. Int. Ed., 2021, 60, 25485 Over the study period, 17,775 patients on MV were treated only in non-ICU settings, whereas 20,516 patients were treated at least once in ICUs (46.4% vs. 53.6%). Average age was higher in non-ICU patients than in ICU patients (72.8 vs. 70.2, P< 0.001). Mean number of ventilation days was greater in non-ICU patients (11.7 vs. 9.5, P< 0.001). Hospital mortality was higher in non-ICU patients (41.4% vs. 38.8%, P< 0.001). Standard critical care (e.g., arterial line placement, enteral nutrition, and stress-ulcer prevention) was provided significantly less often in non-ICU patients. Multivariate analysis showed that ICU admission significantly decreased hospital mortality (adjusted odds ratio 0.713, 95% CI 0.676 to 0.753). Conclusions Li G, Magana D, Dyer RB (2014) Anisotropic energy flow and allosteric ligand binding in albumin. Nat Commun 5:3100 In 1977 IBM introduced the 3250 Display System (manufactured by Sanders Associates) as an upgrade to the 2250. [4] See also [ edit ]

Hawe A, Sutter M, Jiskoot W (2008) Extrinsic fluorescent dyes as tools for protein characterization. Pharm Res 25:1487–1499 The causative link between the cytotoxicity of GP‐2250 and the inhibition of the glycolytic enzymes and the TCA cycle was demonstrated in two rescue experiments. The ability of supplementary OAA and PYR to largely rescue tumour cells from drug‐induced cytotoxicity is evidence that the deficit in glycolytic and TCA cycle‐dependent energy metabolism is the major cause for the cytotoxicity of GP‐2250 (Figure 3A–D). Geng Z., Wang D. B., Zhang C. M., Zhou X. Y., Xin H. F., Liu X. P., Cai M., Int. J. Hydrog. Energy, 2014, 39, 13643 Magde D, Rojas GE, Seybold PG (1999) Solvent dependence of the fluorescence lifetimes of xanthene dyes. Photochem Photobiol 70:737–744

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Choe K., Zheng F. B., Wang H., Yuan Y., Zhao W. S., Xue G. X., Qiu X. Y., Ri M., Shi X. H., Wang Y. L., Li G. D., Tang Z. Y., Angew. Chem. Int. Ed., 2020, 59, 3650 Ideally, critically ill patients requiring life-sustaining interventions should be treated in the ICU. However, one study showed that 16–51% of patients who need critical care are refused ICU admission because of limited resources [ 10]. In a large number of countries, despite limited ICU beds, the majority of acute patients on MV are still treated in ICUs [ 4], whereas in Japan patients on MV may be treated in non-ICU settings. We defined an ICU here as an “officially certified ICU.” Some of the quasi-ICU facilities in our study may well have been similar to ICUs. However, because admission fees are higher in certified ICUs, it is not likely that any certifiable facility would not obtain certification. Therefore, quasi-ICU units are likely to be inferior to certified ICUs in some regard.

To test whether GP‐2250 might inhibit the NF‐kB pathway, p65/DNA binding was analysed in nuclear lysates prepared from Panc Tul and BxPC3 cells, which had been treated for 24h with various concentrations of GP‐2250. GP‐2250 caused a concentration‐dependent inhibition of p65/DNA binding in both cell lines, which was significant already at 250μM and reached 42.1% in Panc TuI (500μM) and 19.7% in BxPC3 (500μM). Bay 117082 served as control 18 (Figure 4C,D). In addition, when lysates from untreated Panc Tul and BxPC3 cells were incubated with the same concentrations of GP‐2250, a comparable degree of inhibition of p65/DNA binding was found (Figure 4E,F). This result supports the view that GP‐2250 is able to directly inhibit p65/DNA binding. A display list of line segments ( vectors) on a 1024 by 1024 grid was stored in computer's memory or an optional buffer on the 2250 and repainted on the 2250's CRT up to 40 times per second. The computer altered the display by changing the display list. Fischer M, Georges J (1997) Use of thermal lens spectrometry for the investigation of dimerization equilibria of rhodamine 6G in water and aqueous micellar solutions. Spectrochim Acta A Mol Biomol Spectrosc 53:1419–1430 Weerasinghe AJ, Schmiesing C, Varaganti S, Ramakrishna G, Sinn E (2010) Single- and multiphoton turn-on fluorescent Fe3+ sensors based on Bis(rhodamine). J Phys Chem B 114:9413–9419 Iwashita Y, Sanui M, Imai H. An attitude survey on doctors treating critically ill patients in hospitals without ICU facilities. J Jpn Assoc Acute Med. 2016;27:175–83.

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Hemmer E, Benayas A, Legare F, Vetrone F (2016) Exploiting the biological windows: current perspectives on fluorescent bioprobes emitting above 1000 nm. Nanoscale Horiz 1:168–184 Ardkhean R., Caputo D. F. J., Morrow S. M., Shi H., Xiong Y., Anderson E. A., Chem. Soc. Rev., 2016, 45, 1557