People with certain medical conditions — such as celiac disease, cancer, Crohn’s disease, alcoholism, hypothyroidism, and anorexia — are more likely to develop nutrient deficiencies, including B vitamins ( 16, 17, 18, 19, 20). In fact, one study found that people’s bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( 5). Another major difference between methylcobalamin and cyanocobalamin is the way they’re absorbed and retained within your body. Since B vitamins are water-soluble, it’s unlikely that you will consume too much of these nutrients through food or by taking a B-complex supplement as directed. Methylation requires a specific B vitamin to be present in the body – 5-MTHF (also known as methylfolate).

Deficiencies in vitamin B6 and folate are also common in older adults ( 14, 15). Those with certain medical conditions Another study in young adults showed that supplementing with a multivitamin containing high levels of B-complex vitamins for 90 days reduced stress and mental fatigue ( 28). May reduce symptoms of anxiety or depression Note that low blood levels of certain B vitamins, including B12, B6, and folate, have been linked to an increased risk of depression, which is why it’s important to rule out nutrient deficiencies if you are experiencing symptoms of depression ( 31, 32). Summary A 33-day study in 215 healthy men found that treatment with a high dose B-complex and mineral supplement improved general mental health and stress and enhanced performance on cognitive tests ( 27). Although these vitamins share some characteristics, they all have unique functions and are needed in different amounts.However, certain circumstances increase the need for B vitamins, making supplements necessary. People who are pregnant or nursing

A daily B-complex vitamin can help ensure that people who choose to follow diets that eliminate animal products are getting enough of these important nutrients. People taking certain medications

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Vitamin B12 and folate contribute to normal blood formation, normal homocysteine metabolism, normal psychological function, and help reduce tiredness and fatigue

Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( 6).

Unlike cyanocobalamin, methylcobalamin is a naturally occurring form of vitamin B12 that can be obtained through supplements, as well as food sources like fish, meat, eggs, and milk ( 3, 4). SUMMARY