Buccolam 10 mg oromucosal solution - Summary of Product Characteristics (SmPC)". (emc). 7 June 2022 . Retrieved 16 June 2022. a b Classen DC, Pestotnik SL, Evans RS, Burke JP (1992). "Intensive surveillance of midazolam use in hospitalized patients and the occurrence of cardiorespiratory arrest". Pharmacotherapy. 12 (3): 213–216. doi: 10.1002/j.1875-9114.1992.tb04512.x. PMID 1608855. S2CID 42657347.

The drug does not cause an individual to become unconscious, merely to be sedated. [7] It is also useful for the treatment of prolonged (lasting over 5 minutes) seizures. [9] Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek. [7] [9] When given intravenously, it typically begins working within five minutes; when injected into a muscle, it can take fifteen minutes to begin working. [7] Effects last between one and six hours. a b Rastegar DA, Fingerhood MI (2005). Addiction medicine: an evidence-based handbook. Philadelphia, PA: Lippincott Williams Wilkins. p.80. ISBN 978-0-7817-6154-3. In the final stages of end-of-life care, midazolam is routinely used at low doses via subcutaneous injection to help with agitation, restlessness or anxiety in the last hours or days of life. [31] At higher doses during the last weeks of life, midazolam is considered a first line agent in palliative continuous deep sedation therapy when it is necessary to alleviate intolerable suffering not responsive to other treatments, [32] but the need for this is rare. [33] Administration [ edit ]

Tools, face masks, spot creams, exfoliators, boosters, facial peels...these are the special treatments that aren’t necessarily a part of your daily regimen but can be incorporated whenever you’re looking for a specific result. That’s because facial treatments are usually more intensive than your other skincare, either because the formula sits on the skin for long periods of time (like a facial mask) or because the product is made with ingredients that are too powerful to be used daily—such as our Doctor's Visit Instant Resurfacing Mask. The Best Facial Masks and Skin Treatments Midazolam was patented in 1974 and came into medical use in 1982. [13] It is on the World Health Organization's List of Essential Medicines. [14] Midazolam is available as a generic medication. [11] In many countries, it is a controlled substance. [7] Medical uses [ edit ] Seizures [ edit ] Sadly, I didn't get anywhere close to the dewy glow that I had hoped I would get after seeing the initial TikTok. But even though I didn't end up looking like a glazed doughnut, my face definitely felt more hydrated. The texture is super satisfying Blinder A (13 March 2017). "When a Common Sedative Becomes an Execution Drug". The New York Times. ISSN 0362-4331. Archived from the original on 14 March 2017 . Retrieved 15 March 2017. Plenty of reviewers with a range of skin care issues, from acne to hyperpigmentation have raved about the results that they've noticed after using the formula.

a b Watkins M (15 October 2013). "Happ executed using new drug". The Gainesville Sun. Archived from the original on 12 December 2013. Sofou K, Kristjánsdóttir R, Papachatzakis NE, Ahmadzadeh A, Uvebrant P (August 2009). "Management of prolonged seizures and status epilepticus in childhood: a systematic review". Journal of Child Neurology. 24 (8): 918–926. doi: 10.1177/0883073809332768. PMID 19332572. S2CID 41731847. The mask is called “instant” for a reason—because of its exfoliating properties, most report a brighter tone and softened texture right away. However, the results get even better over time; apply weekly for four weeks to see significant improvement in the skin. Just don’t forget sunscreen in the morning to protect skin against UV ray damage and pollution, both of which can interfere with results. Because elastin and collagen are responsible for keeping the skin strong and supple, the skin will thin out (resulting in a crepey, papery texture) as it ages. Loss of Firmness and Sagging SkinArcangeli A, Antonelli M, Mignani V, Sandroni C (November 2005). "Sedation in PACU: the role of benzodiazepines". Current Drug Targets. 6 (7): 745–748. doi: 10.2174/138945005774574416. PMID 16305452. In Glossip v. Gross, attorneys for three Oklahoma inmates argued that midazolam could not achieve the level of unconsciousness required for surgery, meaning severe pain and suffering was likely. They argued that midazolam was cruel and unusual punishment and thus contrary to the Eighth Amendment to the United States Constitution. In June 2015, the U.S. Supreme Court ruled that they had failed to prove that midazolam was cruel and unusual when compared to known, available alternatives. [95] a b Udaykumar P (30 May 2008). Short Textbook of Pharmacology for Dental and Allied Health Sciences. Jaypee Brothers Medical Publishers. p.128. ISBN 978-81-8448-149-5.

Midazolam is sometimes used for the acute management of prolonged seizures. Long-term use for the management of epilepsy is not recommended due to the significant risk of tolerance (which renders midazolam and other benzodiazepines ineffective) and the significant side effect of sedation. [15] A benefit of midazolam is that in children it can be given in the cheek or in the nose for acute seizures, including status epilepticus. [16] [17] Midazolam is effective for status epilepticus or when intravenous access cannot be obtained, and has advantages of being water-soluble, having a rapid onset of action and not causing metabolic acidosis from the propylene glycol vehicle (which is not required due to its solubility in water), which occurs with other benzodiazepines. [ citation needed] Hu Z, Yang X, Ho PC, Chan SY, Heng PW, Chan E, etal. (2005). "Herb-drug interactions: a literature review". Drugs. 65 (9): 1239–1282. doi: 10.2165/00003495-200565090-00005. PMID 15916450. S2CID 46963549.Ho KM, Ismail H (May 2008). "Use of intrathecal midazolam to improve perioperative analgesia: a meta-analysis". Anaesthesia and Intensive Care. 36 (3): 365–373. doi: 10.1177/0310057X0803600307. PMID 18564797. S2CID 19088163. Merritt P, Hirshman E, Hsu J, Berrigan M (January 2005). "Metamemory without the memory: are people aware of midazolam-induced amnesia?". Psychopharmacology. 177 (3): 336–343. doi: 10.1007/s00213-004-1958-8. PMID 15290003. S2CID 7142863. This once-weekly mask means business. VERSED Doctor's Visit Instant Resurfacing Mask works in less than three minutes to renew and rejuvenate dull, tired complexions in need. The golden gel- golden from the papaya and pineapple enzymes - exfoliates skin dull, rough skin to deliver visible improvements in clarity and radiance instantly with building results week after week. With three-way exfoliation (AHA, BHA, and enzyme) you can expect uneven texture smoothed, fine lines softened, pores minimized, dark spots brightened. The Details Baselt RC (2008). Disposition of Toxic Drugs and Chemicals in Man (8thed.). Foster City CA: Biomedical Publications. pp.1037–40. ISBN 978-0-9626523-7-0. Seizalam- midazolam hydrochloride injection, solution". DailyMed. Archived from the original on 12 May 2021 . Retrieved 1 January 2021.